50 First Dates (2004) is a romantic comedy directed by Peter Segal. The story follows veterinarian Henry, who falls in love with a woman suffering from amnesia, causing her to forget everything each morning. The leading roles are played by Adam Sandler and Drew Barrymore.. 50 First Dates (2004) is a romantic comedy directed by Peter Segal. The story follows veterinarian Henry, who falls in love with a woman suffering from amnesia, causing her to forget everything each morning. The leading roles are played by Adam Sandler and Drew Barrymore.